巨噬细胞极化
肠道菌群
炎症
脂多糖
巨噬细胞
炎症性肠病
细胞生物学
M2巨噬细胞
疾病
生物
平衡
免疫学
医学
生物化学
内科学
体外
作者
Xin Zhou,Weiyun Li,Shuang Wang,Panli Zhang,Qiong Wang,Jun Xiao,Chi Zhang,Xin Zheng,Xiaoyan Xu,Shifeng Xue,Lijian Hui,Hongbin Ji,Bin Wei,Hongyan Wang
出处
期刊:Cell Reports
[Elsevier]
日期:2019-04-01
卷期号:27 (4): 1176-1189.e5
被引量:221
标识
DOI:10.1016/j.celrep.2019.03.028
摘要
Inflammation, epithelial cell regeneration, macrophage polarization, and gut microbial homeostasis are critical for the pathological processes associated with inflammatory bowel disease (IBD). YAP (Yes-associated protein) is a key component of the Hippo pathway and was recently suggested to promote epithelial cell regeneration for IBD recovery. However, it is unclear how YAP regulates macrophage polarization, inflammation, and gut microbial homeostasis. Although YAP has been shown to promote epithelial regeneration and alleviate IBD, here we show that YAP in macrophages aggravates IBD, accompanied by the production of antimicrobial peptides and changes in gut microbiota. YAP impairs interleukin-4 (IL-4)/IL-13-induced M2 macrophage polarization while promoting lipopolysaccharide (LPS)/interferon γ (IFN-γ)-triggered M1 macrophage activation for IL-6 production. In addition, YAP expression is differently regulated during the induction of M2 versus M1 macrophages. This study suggests that fully understanding the multiple functions of YAP in different cell types is crucial for IBD therapy.
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