关贸总协定3
祖细胞
乳腺癌
生物
祖细胞
下调和上调
癌症研究
癌变
基础(医学)
干细胞
内科学
免疫学
细胞生物学
作者
Ji Ma,Cheng Liu,Decao Yang,Jiagui Song,Jing Zhang,Tianzhuo Wang,Mengyuan Wang,Weizhi Xu,Xueying Li,Shigang Ding,Jun Zhan,Hongquan Zhang
标识
DOI:10.1007/s11427-019-9570-y
摘要
Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes. However, genes that specifically promote basal-like breast cancer development remain largely unknown. Here, we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors. C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in patients. In human TCGA database, C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3, two transcription factors that regulate mammary gland stem cell fate. Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5; depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3. These findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and GATA3. Taken together, we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer.
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