生物
病毒学
病毒
适应(眼睛)
突变
水禽
病毒进化
计算生物学
遗传学
基因
生态学
基因组
神经科学
栖息地
作者
Zhijun Yu,Kaihui Cheng,Tiecheng Wang,Zhiguang Ren,Jiaqiang Wu,Hongbin He,Yuwei Gao
出处
期刊:Virus Research
[Elsevier]
日期:2019-08-01
卷期号:269: 197639-197639
被引量:1
标识
DOI:10.1016/j.virusres.2019.06.002
摘要
After serial passage of a waterfowl-origin H3N2 subtype avian influenza virus in BALB/c mice, we obtained H3N2 mouse-adapted variants and identified eight amino acid substitutions in five viral proteins in our previous study. Here, we analyze the key mutations determining viral pathogenicity in mammals. We found that both PB2-D701N mutation and M1-M192V mutation were implicated in the viral pathogenic phenotypic variation of H3N2 avian influenza virus in mice. Furthermore, we found that PB2-D701N could enhance viral replication in vitro and in vivo and expanded viral tissue tropism. Our data suggest that PB2-D701N and M1-M192V are the virulence markers of H3N2 avian influenza virus, and these markers can be used in the trans-species transmission surveillance for the H3N2 avian influenza virus.
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