烯丙基重排
卡宾
对映选择合成
化学
镍
异构化
催化作用
配体(生物化学)
氧化还原
组合化学
有机化学
药物化学
生物化学
受体
作者
Cai Yuan,Jiawen Zhang,Feng Li,Jiaming Liu,Shi‐Liang Shi
标识
DOI:10.1021/acscatal.8b04198
摘要
The nickel-catalyzed enantioselective redox-neutral coupling of alcohols and alkynes to access chiral allylic alcohols is reported. The reaction proceeds via a hydrogen transfer process under ambient temperature, converting abundant feedstock alcohols and alkynes to chiral allylic alcohols with high stereoselectivities in one chemical step. Key to the success of this process was the development of a bulky chiral N-heterocyclic carbene, (R,R,R,R)-SIPE, a chiral version of SIPr, as the ligand for nickel. Notably, we found that the utilization of P(OPh)3 as secondary ligand for nickel was crucial to inhibit the isomerization of products.
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