旁分泌信号
卵泡闭锁
骨形态发生蛋白15
卵泡期
卵母细胞
卵泡
骨形态发生蛋白
生物
内分泌学
医学
内科学
卵泡发生
细胞生物学
生长分化因子-9
卵巢早衰
遗传学
受体
基因
胚胎
骨形态发生蛋白7
胚胎发生
作者
Meng-Na Liu,Kun Zhang,Tingting Xu
标识
DOI:10.1080/14647273.2019.1672107
摘要
Endocrine and paracrine signals can be key regulators of ovarian physiology. The oocyte secretes growth factors which directly induce follicular development by a complex paracrine signalling process, and the transforming growth factorβ (TGF-β) superfamily has a pivotal role in this process. The bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes are relevant members of the TGF-β superfamily that encode proteins secreted by the oocytes into the ovarian follicles, where they contribute to creating an environment supporting follicle selection and growth. Their main functions include regulating cellular proliferation/differentiation, follicular survival/atresia, and oocyte maturation. Recent functional studies have validated genetic factors (Progesterone receptor membrane component 1 (PGRMC1)), Fragile X mental retardation 1 (FMR1, GDF9 and BMP15) as being causative of primary ovarian insufficiency (POI), BMP15/GDF9 gene variants were found to have a high incidence on the POI phenotype. This review considers the most recent research regarding the role of BMP15 and GDF9 in the genetic control of follicular development, paying special attention to the pathogenesis of POI.
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