An Experimental Analysis of Composite Nursing Material of Degradable Magnesium/Polylactic Acid in the Treatment of Postoperative Pain After Orthopedic Surgery

材料科学 聚乳酸 内固定 复合数 固定(群体遗传学) 氟化镁 医学 外科 复合材料 聚合物 冶金 人口 环境卫生
作者
Yongli Feng,Li Yu,Yanjie Liu,Xiao‐Yuan Wu,Ying Wang,Xiao-Guang Cheng,Yuyan Sun
出处
期刊:Science of Advanced Materials [American Scientific Publishers]
卷期号:12 (6): 842-852
标识
DOI:10.1166/sam.2020.3761
摘要

In this study, magnesium is used as the modified material of polylactic acid (PLA). In the process of combining magnesium and PLA, the magnesium powder is pre-treated with fluorine conversion, that is, the surface of the magnesium powder would form a fluoride membrane, and then it is compounded with PLA to form Mg-F-PA. In the experiment, the morphology of the material is analyzed first. Magnesium powder and magnesium fluoride powder are evenly dispersed on the surface of the composite material, and the surface of the composite material is relatively flat. At the same time, it is found in the mechanical analysis that the mechanical strength of composite Mg-F-PA decreases compared with that of single PLA, but the binding force of magnesium fluoride powder + PLA is stronger than that of magnesium powder + PLA. 120 patients with lower extremity fractures of ASA I∼III are selected and divided into 4 groups, with 30 cases in each group. These patients are treated with hip replacement (group 1), artificial femoral head replacement (group 2), open reduction and internal fixation for lower limb fractures (group 3), open reduction and internal fixation for lower limb fractures + Mg-F-PA (group 4). Then, postoperative evaluation is conducted. The clinical results show that the group 4 is better than the other 3 groups in terms of the sedation degree score, the number of pain pump presses and the incidence of postoperative adverse reactions ( P < 0.05). Therefore, the orthopedic material that proposed in this study can reduce postoperative pain.

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