Introduction: Adherence to prescribed medication is a crucial part of patient care and indispensable for reaching clinical goals. In view of long duration of diabetes, there is a requirement to observe adherence to anti diabetic drugs by patients. In this study 4-item Morisky Medication Adherence Scale (MMAS-4) has been used which is validated in the broadest range of diseases and also in patients with low literacy hence is the most widely used scale for research purposes. Methodology: It was a cross-sectional descriptive observational study for duration of 12 months. A total 400 known patients of type 2 diabetes mellitus from endocrinology outdoor of tertiary care hospital, were recruited and data collected. Adherence to antidiabetics was assessed using Morisky's medication adherence score (four point). Results: Most commonly observed age group was of 40-50 years (mean age 53.76 + 8.84), with male preponderance (57.5%). 67.5% of total were obese (mean BMI 29.79 + 3.26). Adherence to treatment was medium in 66% of the patients.