Chemo-enzymatic access to C -4′-hydroxyl-tetrahydrofurano-spironucleosides

The biocatalytic synthesis of C -4′-hydroxyl-tetrahydrofurano-spironucleosides where the tetrahydrofuranospirocyclic ring at C -4′ position locks the furanose ring of nucleosides in the NE-conformation (C4′- exo ).