巨噬细胞
生物
利基
细胞生物学
免疫系统
功能(生物学)
人口
平衡
免疫
免疫学
生态学
体外
遗传学
医学
环境卫生
作者
Martin Guilliams,Guilhem R. Thierry,Johnny Bonnardel,Marc Bajénoff
出处
期刊:Immunity
[Elsevier]
日期:2020-03-01
卷期号:52 (3): 434-451
被引量:308
标识
DOI:10.1016/j.immuni.2020.02.015
摘要
Self-maintaining resident macrophages populate all mammalian organs. In addition to their role as immune sentinels, macrophages also perform day-to-day functions essential to tissue homeostasis. The homeostatic functions of macrophages are regulated by so-called tissular "niches" that control the size of the macrophage population and imprint tissue-specific identity. Here, we review the mechanisms underlying self-maintenance of distinct macrophage populations and outline the organizing principles of the macrophage niche. We examine recent studies that uncovered mutually beneficial cell-cell circuits established between macrophages and their niche and propose a modular view of tissues that integrates the resident macrophage as an essential component of each individual module. Manipulating macrophage niche cells to control the function of resident macrophages in vivo might have therapeutic value in various disease settings.
科研通智能强力驱动
Strongly Powered by AbleSci AI