医学
低出生体重
出生体重
队列
胰岛素
前瞻性队列研究
儿科
人口
败血症
队列研究
随机对照试验
内科学
怀孕
环境卫生
遗传学
生物
作者
Kathryn Beardsall,Sophie Vanhaesebrouck,Amanda Ogilvy-Stuart,Christine Vanhole,Chris Palmer,Ken K. Ong,Mirjam vanWeissenbruch,Paula Midgley,M. R. Thompson,Marta Thió,Luc Cornette,Iviano Ossuetta,Isabel Iglésias,Claire Theyskens,Miranda de Jong,Bryan Gill,Jag Ahluwalia,Francis de Zegher,David B. Dunger
标识
DOI:10.1016/j.jpeds.2010.04.032
摘要
To investigate the prevalence and determinants of hyperglycemia in the preterm population, as part of the Neonatal Insulin Therapy in Europe (NIRTURE) Trial.We conducted prospective cohort analyses of continuous glucose monitoring data from control infants participating in an international randomized controlled trial. Data were collected from 188 very low birth weight infants (<1500 g).In the first week of life, 80% of infants had evidence of glucose levels >8 mmol/L, and 32% had glucose levels >10 mmol/L >10% of the time. Independent risk factors for hyperglycemia included increasing prematurity, small size at birth, use of inotropes, lipid infusions, and sepsis. There was a lack of association between rate of dextrose infused and risk of hyperglycemia.The prevalence of hyperglycemia in the very low birth weight infant is high, with marked variability in prevalence between infants, not simply related to rates of glucose infused, but to other potentially modifiable risk factors.
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