Sulfonated polyethersulfone(SPES) ultrafiltration membrane was successfully prepared by means of L-S phase inversion method,with SPES as membrane material.The effects of various factors upon the performance of the membrane were studied by uniform experiment design.The prepared technology of SPES ultrafiltration membrane was optimized.The model equation and optimal technologic condition were acquired by means of regress analysis.It was found the flux of the optimum SPES membrane was 90.1 L/(m2·h) and the rejection to PVA was 96.7%.