Comparative study between a new artificial dura mater and autogenous periosteum in replacing orthotopic dura mater

Objective To compare the evolution of a new artificial dura mater and autogenous pefiosteum after replacing respectively orthotopic dura mater by means of performing the skull surgical operations on New Zealand white rabbits and local dogs.Methods All animals were divided into 6 groups.Nine rabbits were divided into 3 groups with 1,6 and 12 month observation respectively(n=3);12 local dogs were divided into 3 groups observed for 12,24 months and longer time period respectively(n=4). The dura mater of each animal was replaced by implanting a new artificial dura and autogenous periosteum. After the operation,the evolution process of the different grafts in each group was observed.Results The zootomy in 6 months or within of the two materials being used to replace the animal's orthotopic dura mater showed no typical significance due to the incomplete cure.The zootomy in 12 months or later showed a little bit easily detachable adhesion of the outside surface of the two replacement materials to the skull perio steum.The animal's orthotopic dura mater sutured around cured completely,without visible interface between the implanted dura and the orthotopic duramater.The inner surface of the two replacement materials showed that the growth of the new biological artificial dura mater is much closer to the orthotopic dura mater,with no adhesion or occasional filamentous adhesion to the brain surface,while there was filamentous adhesion and a little pillar adhesion between the autogenous periosteum and the brain surface. Histological and microscopic observations showed that there were no inflammatory cellular factors such as neutrophil cells, lymphoid cells and so on,and there was no cyst wall at the interface.The inner surface of the new artificial dura mater was seen to be covered with epithelial cells.The proliferations of the fibrous tissues and fibroblast were seen under the epithelia.The implanted material was degraded with a distinct reduction in its total amount.Capillaries were seen inside the material.Conclusion The nature of the new artificial dura mater allowed epithelial cells to grow,avoided the adhesion to the brain tissues and would gradually be encroached,degraded and replaced by the recipient's autologous tissues so that the dura mater could be reconstructed in a practical sense.The study revealed that the new artificial dura mater had a much more practical advantage over the autogenous periosteum in tbe reparation of the injured dura mater.