Primary study on pharmacokinetics of the resveratrol polyphase liposomes in rabbits after oral administration

OBJECTIVE To study the pharmacokinetics of the resveratrol(RES)polyphase liposomes in rabbits after oral administration.METHODS Plasma concentrations of resveratrol in rabbits after oral administration were determined by HPLC.The pharmacokinetics parameters were calculated by 3P97.RESULTS Plasma concentration-time curves of RES and RES polyphase liposomes were both fitted to two-compartment model.The pharmacokinetics parameters of RES polyphase liposomes were calculated as follows:t1/2β=(4.37±0.34)h,AUC0→3=(4.6±0.6)mg·h·L-1,CL=(22.0±2.8)L·kg-1·h-1,Cmax=(3.10±0.07)mg·L-1.The pharmacokinetics parameters of RES solution as follows:t1/2β =(1.07±0.20)h,AUC0→3=(0.97±0.04)mg·h·L-1,CL=(103.3±4.0)L·kg-1·h-1,Cmax =(1.030±0.021)mg·L-1.There were significant difference between RES solution and RES polyphase liposomes.CONCLUSION Our present study demonstrates that compared to RES solution,RES polyphase liposomes significantly alters its pharmacokinetics in rabbits.It can raise AUC and prolong the t1/2βand increase Cmax and reduce CL of RES in the plasma of rabbits.