Objective To explore the therapy of refractory and relapsed AL.Method Treated and observed effects of 38 cases of refractory and relapsed AL by using EAA regimen integrated with AMSA,Ara-c and Vp16.Results Of 38 patients there were 15 cases of complete remission,10 cases of partial remission,and the total effective rate was 65%.Conclusion EAA regimen proved to be an effective therapy in treating refractory and relapsed AL.