STUDIES ON DISSOLUTION OF DRUGS FROM GROUND MIXTURES WITH PREGELATINIZED STARCH

Ground mixtures(GM)of prednisone acetate(PA),indomethacin(IM),daidzein(DD)with pregelatinized starch(PGS)were prepared.The dis-solution test in vitro indicated that GM powder gave a higher rate of dissolutionthan physical mixture(PM)or intact drug powder and that the dissolution rateof drugs from the tablets prepared with GM powder was also significantly greaterthan that from commercial tablets.The various studies suggested that when theweight ratio of each drug with pregelatinized starch was 1:5,drug in GM powderwas in an amorphous state after 90 min of grinding.