In this paper,we investigated the evolution of spiral wave in inhomogeneous medium under feedback interaction with FitzHugh-Nagumo model.It is found that the pattern of the system was changed,when the feedback interaction is appear after the stable spiral emerged in the system.While the intensity of feedback interaction is lower,the feedback interaction made the width of spiral wave narrow;increasing the intensity,the center of spiral wave was broken,and the spiral wave vanished,finally,the system was stable displaying a new pattern.On the other hand,the area of feedback interacted is small,and it is spend long time to break the spiral wave;While the intensity of feedback is high,the spiral wave was broken quickly.