Application of sirolimus in drug-eluting stent

This article summarized the application of sirolimus(rapamycin)in drug-eluting stent(DES) and its working mechanism. A lot of clinical studies have shown sirolimus eluting stent(SES)reduced restenosis rate to less than 10% but sirolimus has also caused lots of problems in the DES. The pharmacological study of sirolimus would help further improvements in SES.