Effects of several inorganic depressant of Na_2S, KMnO_4, H_2O_2, CaCl_2 and Ca(ClO)_2 on the flotability of pyrite and chalcopyrite have been studied. Results show that Na_2S basically has no depressing action on pyrite and chalcopyrite under low-alkaline condition. While KMnO_4, H_2O_2 and CaCl_2 can hardly change the flotability of chalcopyrite, but they will depress pyrite to a certain extent. Ca(ClO_2) is an efficient depressant, and it can successively separate copper from sulfur with a better index.