Advance in Receptor of Infectious bronchitis virus

Avian infectious bronchitis is a worldwide highly contagious infectious pathogen of poultry industry. Its agent,avian infectious bronchitis virus(IBV),is the earliest coronavirus found in the world.The functional cellular receptor involved when the IBV enter the host cell is still one of the hotpoints to research on IBV. A lot of research have dedicated to identify the functional cell receptor. It is known that the protein S on the IBV envelope is the determinant of tissue and cellular tropism of the host. The proteins is usually broken into S1 and S2.S1 bind to the cellular receptor in host cell membrane,then fusion cell membrane in the help of S2, after pH changes,the conformation changes , then got the capability to enter the host cell. This review mainly introduce advances in S1 glycoprotein gene of IBV, and also several probability functional cell receptor involved in virus enter host cell, such as aminopeptidase, sialic acid, heparan sulfate.