自愈水凝胶
神经保护
创伤性脑损伤
材料科学
氧化应激
生物医学工程
神经炎症
活性氧
药理学
炎症
医学
高分子化学
免疫学
内科学
生物化学
化学
精神科
作者
Yuhan Han,Weiji Weng,Yongkang Zhang,Qiyuan Feng,Yuxiao Ma,Ankang Quan,Xianhua Fu,Xinxin Zhao,Loren Skudder-Hill,Jiyao Jiang,Yan Zhou,Honglin Chen,Junfeng Feng
出处
期刊:Biomaterials
[Elsevier]
日期:2024-04-01
卷期号:306: 122495-122495
标识
DOI:10.1016/j.biomaterials.2024.122495
摘要
In managing severe traumatic brain injury (TBI), emergency surgery involving the removal of damaged brain tissue and intracerebral hemorrhage is a priority. Secondary brain injury caused by oxidative stress and energy metabolic disorders, triggered by both primary mechanical brain damage and surgical insult, is also a determining factor in the prognosis of TBI. Unfortunately, the effectiveness of traditional postoperative intravenous neuroprotective agents therapy is often limited by the lack of targeting, timeliness, and side effects when neuroprotective agents systemically delivered. Here, we have developed injectable, intelligent, self-assembling hydrogels (P-RT/2DG) that can achieve precise treatment through intraoperative application to the target area. P-RT/2DG hydrogels were prepared by integrating a reactive oxygen species (ROS)-responsive thioketal linker (RT) into polyethylene glycol. By scavenging ROS and releasing 2-deoxyglucose (2DG) during degradation, these hydrogels functioned both in antioxidation and energy metabolism to inhibit the vicious cycle of post-TBI ROS–lactate which provoked secondary injury. In vitro and in vivo tests confirmed the absence of systemic side effects and the neuroprotective function of P-RT/2DG hydrogels in reducing edema, nerve cell apoptosis, neuroinflammation, and maintaining the blood-brain barrier. Our study thus provides a potential treatment strategy with novel hydrogels in TBI.
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