Protective Effects of AR1001 in Alzheimer’s Disease Models: Polypharmacological Mechanisms

Nitric oxide/cGMP/CREB signaling is critical for learning and memory processes and is disturbed by Abeta amyoid and in Alzheimer's disease. AR1001 is an inhibitor of phosphodiesterase (PDE)-5, which degrades specifically cGMP, thus having a potential to reverse AD pathology.