孟德尔随机化
全基因组关联研究
单核苷酸多态性
遗传关联
荟萃分析
医学
骨质疏松症
内科学
多效性
数量性状位点
硒
SNP公司
肿瘤科
遗传学
生物
遗传变异
基因型
基因
化学
有机化学
表型
作者
Jinjie Li,Hong Li,AZM Ahsan Ullah,Shuyuan Yao,Quanjun Lyu,Guangning Kou
出处
期刊:Nutrients
[MDPI AG]
日期:2023-12-11
卷期号:15 (24): 5065-5065
摘要
Prior research has demonstrated equivocal associations between selenium (Se) concentrations and osteoporosis (OP), yielding inconclusive findings. The purpose of the current study was to examine the potential correlation between Se levels and the risk of OP by using the Mendelian randomization (MR) study design. The genetic variants related to Se levels were obtained from a meta-analysis of a Genome-Wide Association Study (GWAS) conducted on toenail Se levels (n = 4162) and blood Se levels (n = 5477). The data summary for OP and bone mineral density (BMD) was obtained by utilizing the GWAS database. To examine the association between Se levels and BMD and OP, we employed three statistical methods: inverse variance weighted, weighted median, and MR-Egger. The reliability of the analysis was verified by sensitivity testing. All three methods of MR analysis revealed that Se levels had no effect on OP risk. In addition, the sensitivity analysis revealed no heterogeneity or pleiotropy, and the significance of the overall effect remained unaffected by single-nucleotide polymorphisms (SNPs), as determined by the leave-one-out analysis, indicating that our findings are relatively reliable. The results of our study indicate that there is no causal association between Se levels and the risk of OP. However, additional investigation is necessary to ascertain whether there is a potential association between these variables.
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