脂解
材料科学
脂肪组织
白色脂肪组织
脂质代谢
磁制冷
生物相容性
微球
壳聚糖
内科学
内分泌学
生物物理学
癌症研究
医学
生物化学
化学
生物
化学工程
磁场
磁化
物理
量子力学
工程类
冶金
作者
Yu Shibata,Mengyuan Jin,Feifei Chen,Chunsheng Xu,Litian Chen,Li Le,Yeying Li,Mengyuan Zhao,Guo‐Qing Zhu,Zhenkun Lin
标识
DOI:10.1088/1361-6528/ad18e5
摘要
Obesity has become an ongoing global crisis, since it increases the risks of cardiovascular disease, type 2 diabetes, fatty liver, cognitive decline, and some cancers. Adipose tissue is closely associated with the disorder of lipid metabolism. Several efforts have been made toward the modulation of lipid accumulation, but have been hindered by poor efficiency of cellular uptake, low safety, and uncertain effective dosage. Herein, we design an Fe3O4microsphere-doped composite hydrogel (Fe3O4microspheres @chitosan/β-glycerophosphate/collagen), termed as Fe3O4@Gel, as the magnetocaloric agent for magnetic hyperthermia therapy (MHT), aiming to promote lipolysis in white adipocytes. The experimental results show that the obtained Fe3O4@Gel displays a series of advantages, such as fast sol-gel transition, high biocompatibility, and excellent magneto-thermal performance. MHT, which is realized by Fe3O4@Gel subjected to an alternating magnetic field, leads to reduced lipid accumulation, lower triglyceride content, and increased mitochondrial activity in white adipocytes. This work shows that Fe3O4@Gel-mediated MHT can effectively promote lipolysis in white adipocytesin vitro, which provides a potential approach to treat obesity and associated metabolic disorders.
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