放射治疗
神经影像学
临床试验
医学物理学
磁共振成像
胶质母细胞瘤
正电子发射断层摄影术
医学影像学
功能成像
分子成像
医学
放射科
病理
癌症研究
生物技术
精神科
生物
体内
作者
William Breen,Madhava Aryal,Yue Cao,Michelle M. Kim
出处
期刊:Neuro-oncology
[Oxford University Press]
日期:2024-03-01
卷期号:26 (Supplement_1): S17-S25
标识
DOI:10.1093/neuonc/noad187
摘要
Advances in diagnostic and treatment technology along with rapid developments in translational research may now allow the realization of precision radiotherapy. Integration of biologically informed multimodality imaging to address the spatial and temporal heterogeneity underlying treatment resistance in glioblastoma is now possible for patient care, with evidence of safety and potential benefit. Beyond their diagnostic utility, several candidate imaging biomarkers have emerged in recent early-phase clinical trials of biologically based radiotherapy, and their definitive assessment in multicenter prospective trials is already in development. In this review, the rationale for clinical implementation of candidate advanced magnetic resonance imaging and positron emission tomography imaging biomarkers to guide personalized radiotherapy, the current landscape, and future directions for integrating imaging biomarkers into radiotherapy for glioblastoma are summarized. Moving forward, response-adaptive radiotherapy using biologically informed imaging biomarkers to address emerging treatment resistance in rational combination with novel systemic therapies may ultimately permit improvements in glioblastoma outcomes and true individualization of patient care.
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