免疫系统
炎症
免疫
疾病
肾
医学
原发性高血压
肾脏疾病
免疫学
内科学
肠道菌群
内分泌学
生物
生理学
血压
作者
David L. Mattson,John Henry Dasinger,Justine M. Abais-Battad
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2022-11-01
卷期号:79 (11): 2397-2408
被引量:7
标识
DOI:10.1161/hypertensionaha.122.18556
摘要
Humans with salt-sensitive hypertension demonstrate increased morbidity, increased mortality, and renal end-organ damage when compared with normotensive subjects or those with salt-resistant hypertension. Substantial evidence from humans and animals has also demonstrated the role of dietary components other than salt to modulate hypertension. Evidence presented in this review provides support for the view that immunity and inflammation serve to amplify the development of salt-sensitive hypertension and leads to malignant disease accompanied by end-organ damage. Interestingly, salt-sensitive disease is modulated by changes in dietary protein intake, which also influences immune mechanisms. Together, the evidence presented in this review from animal and human studies indicates that changes in dietary protein source have profound effects on the gut microbiota, microbiota-derived metabolites, DNA methylation, gene expression, immune cell activation, the production of cytokines and other factors, and the development of salt-sensitive hypertension and related disease phenotypes.
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