芳香烃受体
痤疮
特应性皮炎
银屑病
医学
疾病
皮肤病
免疫系统
免疫学
生物信息学
转录因子
皮肤病科
生物
病理
生物化学
基因
作者
Michał Dec,Hubert Arasiewicz
标识
DOI:10.5114/ada.2023.135617
摘要
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that has gained increasing attention in the field of dermatology due to its multifaceted role in skin health and disease.This review provides a comprehensive overview of the current state of knowledge regarding the AHR and its implications in dermatological conditions.The AHR is well known for its involvement in xenobiotic metabolism, particularly in response to polycyclic aromatic hydrocarbons and dioxins.However, recent research has unveiled its pivotal role in the skin immune response, barrier function, and homeostasis.The AHR signalling pathway is intricately linked to various dermatological disorders, including psoriasis, atopic dermatitis, acne and hidradenitis suppurativa.In this review, we delve into the molecular mechanisms through which AHR activation influences skin physiology and highlight how dysregulation can lead to pathological conditions.Moreover, we discuss the emerging therapeutic potential of AHR modulators in the treatment of skin diseases.In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology.Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions.Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.
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