抗菌剂
抗生素
抗生素耐药性
抗药性
细菌
药品
致病菌
多重耐药
合理设计
生物
微生物学
生化工程
纳米技术
药理学
材料科学
工程类
遗传学
作者
Kavya Moorthy,Kai‐Chih Chang,Hsin-Chia Yang,Wen‐Min Su,Cheng‐Kang Chiang,Zhiqin Yuan
出处
期刊:Journal of Food and Drug Analysis
[The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)]
日期:2023-03-10
卷期号:31 (1): 1-19
被引量:3
标识
DOI:10.38212/2224-6614.3433
摘要
Owing to the widespread emergence and proliferation of antibiotic-resistant bacteria, the therapeutic benefits of antibiotics have been reduced.In addition, the ongoing evolution of multidrug-resistant pathogens poses a challenge for the scientific community to develop sensitive analytical methods and innovative antimicrobial agents for the detection and treatment of drug-resistant bacterial infections.In this review, we have described the antibiotic resistance mechanisms that occur in bacteria and summarized the recent developments in detection strategies for monitoring drug resistance using different diagnostic methods in three aspects, including electrostatic attraction, chemical reaction, and probe-free analysis.Additionally, to understand the effective inhibition of drug-resistant bacterial growth by recent nano-antibiotics, the underlying antimicrobial mechanisms and efficacy of biogenic silver nanoparticles and antimicrobial peptides, which have shown promise, and the rationale, design, and potential improvements to these methods are also highlighted in this review.Finally, the primary challenges and future trends in the rational design of facile sensing platforms and novel antibacterial agents against superbugs are discussed.
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