骨整合
生物相容性
材料科学
钛
生物医学工程
表面改性
植入
纳米技术
骨组织
牙科
医学
化学工程
外科
工程类
冶金
作者
Zhenbing Ji,Yi Wan,Hongwei Wang,Mingzhi Yu,Zihe Zhao,Teng Wang,Guangqiang Ma,Shiyuan Fan,Qingqing Wang
标识
DOI:10.1088/1748-605x/acd976
摘要
Titanium and its alloys have been widely used in bone tissue defect treatment owing to their excellent comprehensive properties. However, because of the biological inertness of the surface, it is difficult to achieve satisfactory osseointegration with the surrounding bone tissue when implanted into the body. Meanwhile, an inflammatory response is inevitable, which leads to implantation failure. Therefore, solving these two problems has become a new research hotspot. In current studies, various surface modification methods were proposed to meet the clinical needs. Yet, these methods have not been classified as a system to guide the follow-up research. These methods are demanded to be summarized, analyzed, and compared. In this manuscript, the effect of physical signal regulation (multi-scale composite structure) and chemical signal regulation (bioactive substance) generated by surface modification in promoting osteogenesis and reducing inflammatory responses was generalized and discussed. Finally, from the perspective of material preparation and biocompatibility experiments, the development trend of surface modification in promoting titanium implant surface osteogenesis and anti-inflammatory research was proposed.
科研通智能强力驱动
Strongly Powered by AbleSci AI