Details and outcomes of a large cohort of MOG-IgG associated optic neuritis

医学 视神经炎 多发性硬化 队列 队列研究 免疫学 皮肤病科 内科学
作者
John J. Chen,Eoin P. Flanagan,M. Tariq Bhatti,Nanthaya Tisavipat,Sepideh Jamali,Amy Kunchok,Eric Eggenberger,Marie Di Nome,Elias S. Sotirchos,Eleni S. Vasileiou,Amanda D. Henderson,Anthony C. Arnold,Laura Bonelli,Nicolás Seleme,Alvaro J. Mejia-Vergara,Heather E. Moss,Tanyatuth Padungkiatsagul,Hadas Stiebel‐Kalish,Itay Lotan,Adi Wilf‐Yarkoni,Mark A. Hellmann,Amrita-Amanda D. Vuppala,David O. Hodge,Sean J. Pittock
出处
期刊:Multiple sclerosis and related disorders [Elsevier BV]
卷期号:68: 104237-104237 被引量:25
标识
DOI:10.1016/j.msard.2022.104237
摘要

Abstract

Background

The goal of this study was to examine the temporal relationship of eye pain to visual loss and investigate whether timing of steroid treatment affects the rate and extent of visual recovery in optic neuritis (ON) from MOG-IgG associated disease (MOGAD) in a large cohort of MOGAD patients with ON.

Methods

This is a multicenter, retrospective cohort study of consecutive MOGAD patients with ON attacks seen from 2017 to 2021 fulfilling the following criteria: (1) clinical history of ON; (2) MOG-IgG seropositivity. ON attacks were evaluated for presence/duration of eye pain, nadir of vision loss, time to intravenous methylprednisolone (IVMP) treatment, time to recovery, and final visual outcomes.

Results

There were 107 patients with 140 attacks treated with IVMP and details on timing of treatment and outcomes. Eye pain was present in 125/140 (89%) attacks with pain onset a median of 3 days (range, 0 to 20) prior to vision loss. Among 46 ON attacks treated with IVMP within 2 days of onset of vision loss, median time to recovery was 4 days (range, 0 to 103) compared to 15 days (range, 0 to 365) in 94 ON attacks treated after 2 days (p = 0.004). Those treated within 2 days had less severe VA loss at time of treatment (median LogMAR VA 0.48, range, 0.1 to 3) compared to those treated after 2 days (median LogMAR VA 1.7, range, 0 to 3; p < 0.001), and were more likely to have a VA outcome of 20/40 or better (98% vs 83%, p = 0.01). After adjustment for the initial VA at time of treatment, the differences in final VA were no longer significantly different (p = 0.14). In addition, some patients were documented to recover without steroid treatment.

Conclusion

This study suggests that pain precedes vision loss in the majority of ON attacks and early steroids may lead to better outcomes in MOG-IgG ON, but some patients can recover without steroid treatment. Prospective randomized clinical trials are required to confirm these findings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
翟淑雨完成签到,获得积分10
刚刚
ynlqjqx完成签到,获得积分10
1秒前
1秒前
Felixsun发布了新的文献求助10
2秒前
烟绯发布了新的文献求助10
2秒前
VDC发布了新的文献求助10
2秒前
3秒前
吴惜珊发布了新的文献求助10
4秒前
xiechangshan发布了新的文献求助10
4秒前
pdx666发布了新的文献求助10
5秒前
大模型应助胖肉肉采纳,获得10
6秒前
猫小海发布了新的文献求助10
6秒前
健忘的曲奇关注了科研通微信公众号
7秒前
舒适的梦玉完成签到,获得积分10
8秒前
Marcus完成签到,获得积分10
8秒前
9秒前
zzz发布了新的文献求助30
9秒前
光亮的灭绝完成签到 ,获得积分10
10秒前
kong完成签到 ,获得积分10
13秒前
13秒前
Akim应助Felixsun采纳,获得10
14秒前
15秒前
16秒前
吴惜珊完成签到,获得积分10
16秒前
yiqifan完成签到,获得积分0
18秒前
彭于晏应助xiechangshan采纳,获得10
18秒前
junsizzz完成签到,获得积分10
18秒前
胡图图完成签到 ,获得积分10
18秒前
19秒前
胖肉肉发布了新的文献求助10
19秒前
LeAve发布了新的文献求助10
21秒前
junjie发布了新的文献求助10
22秒前
XJTU_jyh完成签到,获得积分10
22秒前
神勇友灵完成签到,获得积分10
22秒前
22秒前
我是老大应助sss采纳,获得30
24秒前
科目三应助胖肉肉采纳,获得10
24秒前
猫小海完成签到,获得积分10
25秒前
笨笨无色完成签到,获得积分20
26秒前
烟绯完成签到 ,获得积分10
26秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
The First Nuclear Era: The Life and Times of a Technological Fixer 500
Unusual formation of 4-diazo-3-nitriminopyrazoles upon acid nitration of pyrazolo[3,4-d][1,2,3]triazoles 500
岡本唐貴自伝的回想画集 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3671598
求助须知:如何正确求助?哪些是违规求助? 3228309
关于积分的说明 9779385
捐赠科研通 2938622
什么是DOI,文献DOI怎么找? 1610143
邀请新用户注册赠送积分活动 760547
科研通“疑难数据库(出版商)”最低求助积分说明 736093