配体(生物化学)
铁
背景(考古学)
磁弛豫
化学
氨基甲酸酯
铁离子
结晶学
核磁共振
物理
无机化学
有机化学
磁场
古生物学
生物化学
生物
受体
磁化
量子力学
作者
Jérémy Salaam,Thibault Fogeron,Guillaume Pilet,Radu Bolbos,Christophe Bucher,Lhoussain Khrouz,Jens Hasserodt
标识
DOI:10.1002/anie.202212782
摘要
Two mononuclear ferric complexes are reported that respond to a pH change with a 27- and 71-fold jump, respectively, in their capacity to accelerate the longitudinal relaxation rate of water-hydrogen nuclei, and this starting from a negligible base value of only 0.06. This unprecedented performance bodes well for tackling the sensitivity issues hampering the development of Molecular MRI. The two chelates also excel in the fully reversible and fatigue-less nature of this phenomenon. The structural reasons for this performance reside in the macrocyclic nature of the hexa-dentate ligand, as well as the presence of a single pendant arm displaying a five-membered lactam or carbamate which show (perturbed) pKa values of 3.5 in the context of this N6 ⇔${ \Leftrightarrow }$ N5O1 coordination motif.
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