多囊卵巢
不利影响
生殖健康
环境卫生
医学
生殖毒性
烟草烟雾
不育
毒理
怀孕
生物
毒性
内科学
人口
肥胖
胰岛素抵抗
遗传学
作者
Ata Rafiee,Mohammad Hoseini,Sadaf Akbari,E. Melinda Mahabee‐Gittens
出处
期刊:Reviews on environmental health
[De Gruyter]
日期:2023-01-02
被引量:4
标识
DOI:10.1515/reveh-2022-0182
摘要
Abstract Objectives Polycyclic Aromatic Hydrocarbons (PAHs) are ubiquitous, toxic environmental chemicals that can cause adverse reproductive health effects. The objectives of this mini-review are to highlight the adverse reproductive outcomes due to PAH exposure with the main focus on polycystic ovary syndrome (PCOS) and premature ovarian failure (POF) and to provide perspectives on future research needs. Content We reviewed studies that have reported the adverse reproductive outcomes associated with PAHs exposures in women through a comprehensive search of bibliographic databases and gray literature sources. In addition, potentially modifiable sources of exposure to PAHs and associated reproductive outcomes were also investigated. Summary A total of 232 papers were retrieved through a comprehensive search of bibliographic databases, out of which three studies met the eligibility criteria and were included in the review. Results showed that exposure to PAHs is associated with adverse reproductive outcomes defined as PCOS, POF, and reproductive hormone imbalance. Sources of PAH exposure associated with adverse reproductive outcomes include active and passive tobacco smoking, specific cooking methods, and pesticides. Outlook Future studies are warranted to examine the mechanisms by which PAHs result in adverse reproductive endpoints in women. Further, environmental exposures that are potentially modifiable such as exposure to tobacco smoke, may contribute to PAH exposure, and these exposures should be targeted in future policies and interventions.
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