脂肪性肝炎
纤维化
肝硬化
表观遗传学
医学
疾病
生物信息学
肝病
癌症研究
脂肪肝
病理
生物
内科学
遗传学
基因
作者
Shuang Wang,Scott L. Friedman
标识
DOI:10.1126/scitranslmed.adi0759
摘要
Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease that poses a global health threat because of its potential to progress to advanced fibrosis, leading to cirrhosis and liver cancer. Recent advances in single-cell methodologies, refined disease models, and genetic and epigenetic insights have provided a nuanced understanding of MASH fibrogenesis, with substantial cellular heterogeneity in MASH livers providing potentially targetable cell-cell interactions and behavior. Unlike fibrogenesis, mechanisms underlying fibrosis regression in MASH are still inadequately understood, although antifibrotic targets have been recently identified. A refined antifibrotic treatment framework could lead to noninvasive assessment and targeted therapies that preserve hepatocellular function and restore the liver’s architectural integrity.
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