Analysis of the mechanism of action of Euphorbia fischeriana Steud on cirrhosis based on network pharmacology

小桶 系统药理学 计算生物学 药理学 联机孟德尔在人类中的遗传 作用机理 医学 药物数据库 机制(生物学) 中医药 信号转导 生物信息学 生物 生物化学 转录组 基因 基因表达 表型 哲学 替代医学 药品 认识论 病理 体外
作者
Lu Liu,Yinliang Xu,Liu Yang,Zhenzhong Jiang,Xiaoyan Li
出处
期刊:Medicine [Wolters Kluwer]
卷期号:102 (37): e35118-e35118
标识
DOI:10.1097/md.0000000000035118
摘要

This study aimed to employ network pharmacology to elucidate the mechanism by which Euphorbia fischeriana Steud (EFS) exhibits the efficacy on cirrhosis. The compounds and targets of EFS were retrieved from Traditional Chinese Medicine Integrated Database and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Next, these compounds and targets were analyzed based on protein-protein interaction (PPI) network. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling network was established based on KEGG database. We constructed a compound-compound target-intersection target-pathway PPI network, including 20 compounds, 19 intersection targets between compound targets and EFS targets. Among the 20 compounds, 8-Isopentenyl-kaempferol has the most targets, with 27 targets, followed by 3,4',5-Trihydroxy-7-methoxy-8-isopentenylflavone, Formononetin, Isoxanthohumol, and Isokurarinone with potential targets of 26, 22, 18, and 14, respectively. Top 5 targets are HSP90AA1, PTGS2, NOS2, MAPK14, and PPARG. KEGG pathway enrichment analysis showed that pathways such as Hepatitis B, Hepatitis C, Lipid and atherosclerosis, and AGE-RAGE signaling pathway in diabetic complications were closely related to the infection and abnormal metabolism of the liver. The application of network pharmacology could identify potential targets of EFS with a low false-positive rate and provide novel insight into the mechanism of action of EFS on cirrhosis.
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