化学
喹啉酮
咪唑
盐酸盐
催化作用
有机化学
组合化学
药物化学
作者
Yin Wang,Xiuyu Zhang,Suzhen Li,Mei Guo,Wanqian Ma,Jianyong Yuan
出处
期刊:Current Organic Synthesis
[Bentham Science]
日期:2023-08-15
卷期号:21
标识
DOI:10.2174/1570179421666230815151540
摘要
As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed a wide range of functional group tolerance, and a series of quinazolinones were synthesized in low to moderate yields without metal catalysts, oxidants or other additives.
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