Tiam1 creates a painful link between dendritic spine remodeling and NMDA receptors

Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents. Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents. Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic painLi et al.NeuronMay 4, 2023In BriefCurrent treatment options for neuropathic pain are limited. In this study, Li et al. identify Tiam1-coordinated maladaptive synaptic structural and functional plasticity in spinal excitatory neurons as the pathophysiological mechanism that initiates, transits, and sustains neuropathic pain, thus providing a promising therapeutic target to treat neuropathic pain effectively. Full-Text PDF