炔烃
立体选择性
化学
催化作用
卤化物
分子内力
镍
选择性
分子间力
组合化学
药物化学
立体化学
有机化学
分子
作者
Huan Li,Fang Wang,Shuaishuai Zhu,Lingling Chu
标识
DOI:10.1002/anie.202116725
摘要
We describe here a Ni-catalyzed intermolecular carbo-fluoromethylation of alkynes with aliphatic halides and fluoromethyl halides (BrCF2 H and ICH2 F) in the presence of zinc, enabling the facile and selective access to a diverse range of biologically valuable CF2 H/CH2 F-incorporated alkenes with excellent regio- and stereoselectivity. Notably, merging intramolecular radical cyclization with fluoromethyl coupling enables the expedient constructions of CF2 H/CH2 F-incorporated lactones and lactams with high efficiency and selectivity. Mechanistic studies disclose that this catalytic protocol proceeds via a radical addition to an alkyne followed by selective coupling with the fluoromethyl unit.
科研通智能强力驱动
Strongly Powered by AbleSci AI