医学
荟萃分析
优势比
置信区间
支架
科克伦图书馆
合并分析
子群分析
胆道引流
胰腺癌
内科学
不利影响
胃肠病学
外科
癌症
作者
Yasunobu Yamashita,Ayaka Tachikawa,Toshio Shimokawa,Hirofumi Yamazaki,Masahiro Itonaga,Yuji Sakai,Harutoshi Sugiyama,Yousuke Nakai,Kiyohito Tanaka,Hiroyuki Isayama,Masayuki Kitano
摘要
Objectives The role of a covered vs. an uncovered self‐expandable metal stent (SEMS) for malignant distal biliary obstruction (MDBO) is not clear. This meta‐analysis compared the efficacy of covered vs. uncovered SEMS for patients with MDBO after endoscopic insertion. Methods A systematic meta‐analysis of all relevant articles listed in PubMed, the Cochrane Library, and Google Scholar databases was performed. Fixed effects or random effects models were used to investigate pooled effects with 95% confidence intervals (CIs). Results The meta‐analysis included 2358 patients from 12 eligible studies. Time to recurrent biliary obstruction (RBO) was significantly longer for covered SEMS (mean difference, 45.51 days; 95% CI 11.79–79.24). Although there was no significant difference in the RBO rate, subgroup analysis in pancreatic cancer occupying more than 90% (PC) revealed that the RBO rates were significantly lower for covered SEMS (odds ratio [OR] 0.43, 95% CI 0.25–0.74). Stent migration, sludge formation, and overgrowth were significantly more common with a covered SEMS (OR 7.92, 95% CI 4.01–15.64; OR 3.25, 95% CI 1.89–5.59; OR 2.03, 95% CI 1.20–3.43, respectively). The rate of ingrowth was significantly lower for covered SEMS. There was no significant difference in total procedure‐related adverse events between the two types of SEMS. Conclusions A covered SEMS is superior to an uncovered SEMS with respect to prevention of RBO in patients with MDBO, particularly those caused by PC.
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