Design and Synthesis of Spirocycles via Olefin Metathesis

Design and synthesis of novel spirocyclic compounds is a challenging task in organic and medicinal chemistry because of the generation of quaternary center, which holds central chirality or an axial chirality. This chapter includes various strategies that utilize metathesis for the construction of spirocycles in combination withother well-known name reactions, such as Claisen rearrangement, Grignard addition, Fischer indolization, Suzuki–Miyaura, cross-coupling, and retro Diels–Alder reaction. The catalysts used to realize the metathesis sequence for the synthesis of spirocycles are Grubbs first-generation catalyst, Grubbs second-generation catalyst, Hoveyda–Grubbs first-generation catalyst, and Hoveyda–Grubbs second-generation catalyst. The chapter provides the information on the formation of aza-spirocycles, and the formation of oxa-spirocycles.