结晶
成核
材料科学
亚稳态
再结晶(地质)
结晶学
多态性(计算机科学)
粒径
粒度分布
灵霉素
结晶度
化学工程
过饱和度
化学
物理化学
有机化学
工程类
古生物学
基因型
致幻剂
精神科
基因
生物
生物化学
心理学
作者
Robert B. Kargbo,Alexander M. Sherwood,Poncho Meisenheimer,Kelsey Lenoch,Solomon B. Abebe
出处
期刊:ACS omega
[American Chemical Society]
日期:2022-02-07
卷期号:7 (6): 5429-5436
被引量:1
标识
DOI:10.1021/acsomega.1c06708
摘要
Psilocybin, a serotonergic agonist, was granted a "breakthrough therapy" status by the Food and Drug Administration for clinical trials involving major depressive disorder and treatment-resistant depression. The direct phosphorylation of psilocin to psilocybin that uses a fast crystallization associated with a kinetically controlled process resulted in a smaller particle size distribution. Herein, the measurement of the metastable zone width (MSZW) and nucleation induction enabled a thermodynamically controlled crystallization process, which leads to the formation of a crystal structure with stronger interactions, controlled particle size distribution (PSD), and improved impurity profile. Employing a high-resolution inline microscopy viewer allowed the real-time monitoring of the crystallization process and the measurement of the particle size. We also present a comprehensive study of the formation of polymorph B (trihydrate), polymorph A (anhydrate), and polymorph H (anhydrate) using water recrystallization, which indicates that the formation of polymorph B (trihydrate) is independent of the crystallization method. However, polymorphs A and H are dependent on the mode of drying: drying at room temperature under vacuum gives rise to mainly polymorph A, and when heated even at relatively low temperatures, a mixture of polymorphs A and H beings to form.
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