合成子
碳负离子
试剂
格氏试剂
化学
亲核细胞
组合化学
有机合成
有机化学
催化作用
作者
Ramesh Samineni,Vishnuvardhana Eda,Praveen Rao,Saikat Sen,Srinivas Oruganti
标识
DOI:10.1002/slct.202102853
摘要
Abstract Grignard reagents are routinely employed in the pharmaceutical industry as reliablesynthetic equivaents of carbanion synthons for construction of new C−C bonds. The present review however does not focuson these well documented applications of Grignard reagents as carbon nucleophiles. Rather, it documents certain unique case studies wherein, despite the material loss entailed as R−H, a Grignard reagent (RMgX) was strategically deployed as a Bronsted base to abstract an active hydrogen and effect a desired transformation in the synthesis of APIs and pharmaceutically relevant natural products.
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