催产素
加压素
神经肽
侵略
社会行为
神经科学
催产素受体
心理学
垂体后叶
激素
生物神经网络
内分泌学
自闭症谱系障碍
内科学
自闭症
发展心理学
医学
垂体
受体
作者
Nicole Rigney,Geert J. De Vries,Aras Petrulis,Larry J. Young
出处
期刊:Endocrinology
[The Endocrine Society]
日期:2022-07-21
卷期号:163 (9)
被引量:43
标识
DOI:10.1210/endocr/bqac111
摘要
Oxytocin and vasopressin are peptide hormones secreted from the pituitary that are well known for their peripheral endocrine effects on childbirth/nursing and blood pressure/urine concentration, respectively. However, both peptides are also released in the brain, where they modulate several aspects of social behaviors. Oxytocin promotes maternal nurturing and bonding, enhances social reward, and increases the salience of social stimuli. Vasopressin modulates social communication, social investigation, territorial behavior, and aggression, predominantly in males. Both peptides facilitate social memory and pair bonding behaviors in monogamous species. Here we review the latest research delineating the neural circuitry of the brain oxytocin and vasopressin systems and summarize recent investigations into the circuit-based mechanisms modulating social behaviors. We highlight research using modern molecular genetic technologies to map, monitor activity of, or manipulate neuropeptide circuits. Species diversity in oxytocin and vasopressin effects on social behaviors are also discussed. We conclude with a discussion of the translational implications of oxytocin and vasopressin for improving social functioning in disorders with social impairments, such as autism spectrum disorder.
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