自愈水凝胶
微尺度化学
微技术
细胞外基质
纳米技术
肿瘤细胞
小学(天文学)
原发性肿瘤
材料科学
化学
细胞生物学
癌症
生物
癌症研究
心理学
物理
数学教育
遗传学
高分子化学
转移
天文
作者
Yiyang Jia,Zhentong Wei,Songling Zhang,Bai Yang,Yunfeng Li
标识
DOI:10.1002/adhm.202102479
摘要
Primary tumor organoids (PTOs) growth in hydrogels have emerged as an important in vitro model that recapitulates many characteristics of the native tumor tissue, and have important applications in fundamental cancer research and for the development of useful therapeutic treatment. This paper begins with reviewing the methods of isolation of primary tumor cells. Then, recent advances on the instructive hydrogels as biomimetic extracellular matrix for primary tumor cell culture and construction of PTO models are summarized. Emerging microtechnology for growth of PTOs in microscale hydrogels and the applications of PTOs are highlighted. This paper concludes with an outlook on the future directions in the investigation of instructive hydrogels for PTO growth.
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