Machine Learning–Assisted Diagnostic System for Indeterminate Thyroid Nodules

To develop an ultrasound-based machine learning classifier to diagnose benignity within indeterminate thyroid nodules (ITNs) by fine-needle aspiration, 180 patients with 194 ITNs (Bethesda classes III, IV and V) undergoing surgery over a 5-y study period were analyzed. The data set was randomly divided into training and testing data sets with 155 and 39 ITNs, respectively. All nodules were evaluated by ultrasound using the American College of Radiology Thyroid Imaging Reporting and Data System by manually scoring composition, echogenicity, shape, margin and echogenic foci. Nodule size, participant age and patient sex were recorded. A support vector machine (SVM) model with a cost-sensitive approach was developed using the aforementioned eight parameters with surgical histopathology as the reference standard. Surgical pathology determined 90 (46.4%) ITNs were malignant and 104 (53.6%) were benign. The SVM model classified 14 nodules as benign in the testing data set, of which 13 were correct (sensitivity = 93.8%, specificity = 56.5%). Considering malignancy prevalence by Bethesda group, the negative predictive values of this model for Bethesda III and IV categories were 93.9% and 93. 8%, respectively. The high negative predictive value of the SVM ultrasound-based model suggests a pathway by which surgical excision of Bethesda III and IV ITNs classified as benign may be avoided.