The topic of injection lipolysis remains controversial even 5 years after of becoming a popular treatment for reducing localized fat deposits with injections rather than surgery. The technique was invented by Rittes who had studied mesotherapy with Lecoz in France. A patient, knowing of Rittes skill with injections, requested an injectable fat reduction for her lower lid bags. The patient persisted despite the absence of an injectable technique for localized fat reduction at that time. Rittes researched the pharmaceutical and clinical literature for a solution. She found Bobkova’s article describing the endovenous plaque reducing qualities in Lipostabil, a Sanofi Aventis drug containing phosphatidylcholine (PC) made from soy lecithin [1]. Rittes’ paper, published in 2001 [2], is often quoted as the origin of the injection lipolysis procedure.