川地34
免疫组织化学
胃癌
癌症
病理
淋巴结
临床意义
阶段(地层学)
癌
渗透(HVAC)
医学
生物
癌症研究
内科学
干细胞
古生物学
遗传学
物理
热力学
作者
Li Chen,Xinyu Li,Guei-lan Wang,Yu Wang,York-Yuan Zhu,Jun Zhu
标识
DOI:10.1177/030089160809400415
摘要
To investigate the expression of TSPAN1 (Gene ID: 10103), Ki67 and CD34 in gastric carcinomas and the clinicopathological significance, the expression of TSPAN1, Ki67 and CD34 was detected in 86 cases of gastric carcinoma, paraffin-embedded sections using an immunohistochemical method. The rates of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinomas were 56.98%, 74.42%, and 62.79%, respectively. The overexpression of these markers was positively correlated with clinical stage and negatively correlated with survival rates (at 3 and 5 years). The overexpression of TSPAN1 and Ki67 was negatively correlated with carcinoma differentiation, and the overexpression of TSPAN1 and CD34 was positively correlated with infiltration and lymph node status of the tumor. Thus, overexpression of TSPAN1, Ki67 and CD34 in gastric cancer tissues is associated with development of the cancer. The detection of expression of TSPAN1, Ki67 and CD34 in gastric cancer may provide useful prognostic information for patients with the disease.
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