生物
酿酒酵母
多重耐药
突变体
表型
基因
遗传学
遗传筛选
酵母
ATP结合盒运输机
转录调控
抗药性
运输机
细胞生物学
基因表达
出处
期刊:Progress in Nucleic Acid Research and Molecular Biology
日期:2003-01-01
卷期号:: 251-279
被引量:98
标识
DOI:10.1016/s0079-6603(03)01008-0
摘要
A major problem in chemotherapeutic treatment of many pathological conditions including cancer and fungal infections is the development of a multidrug-resistant state in the target cell. Saccharomyces cerevisiae cells can be isolated that have single genetic alterations that cause the resulting mutant strains to become tolerant of a wide range of compounds that would otherwise be toxic. These mutant cells are referred to as having a pleiotropic drug-resistant (Pdr) phenotype. Studies of these Pdr cells have demonstrated that mutations either within genes encoding transcriptional regulators or in their regulatory inputs lead to overexpression of downstream transporter proteins with associated multidrug resistance. This review is aimed at providing a framework for understanding the networks modulating expression of PDR genes in S. cerevisiae.
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