Toxicity abounds in nature, environment, and in our modern life-style. Toxicology relates to the study of the intake process of such toxins by human being, their mode of propagation, biological reactions, molecular level of penetration, genotoxicity and aftermaths. Because of the latent nature of a large class of toxic substances, the extreme variability of human metabolism as well as their exposure to toxic material, yet unknown nature of many carcinogentic activities, and immense difficulties in the assessment of effective toxicity levels (especially in the environment), there is a genuine need to have statistical perspectives are highlighted here along with some outline of recent statistical approaches in this much needed assessment task.