医学
内科学
细胞减少
淋巴瘤
化疗
三氧化二砷
无症状的
肿瘤科
蒽环类
多发性骨髓瘤
中止
心脏毒性
胃肠病学
病理
骨髓
癌症
乳腺癌
化学
细胞凋亡
生物化学
作者
Alessandro Allegra,Andrea Alonci,Salvatore Russo,Antonino Cannavò,Giuseppa Penna,Arianna D’Angelo,Giacomo Bellomo,Caterina Musolino
出处
期刊:PubMed
日期:2010-10-01
卷期号:58 (7): 859-74
被引量:7
标识
DOI:10.231/jim.0b013e3181efbc4e
摘要
Authors have reviewed literature about the management of patients with cardiologic disease occurring secondary to hematologic pathology itself or its therapy, with a focus on infiltration of myocardium in acute and chronic leukemia, lymphoma, multiple myeloma, and hypereosinophilic syndrome. Moreover, they evaluated chemotherapy-associated toxicity, particularly for new drugs such as monoclonal antibody therapy, tyrosine kinase inhibitors, arsenic trioxide, bortezomib, and epigenetic therapy. In fact, cardiac toxicity may range from asymptomatic subclinical abnormalities, such as electrocardiographic changes and left ventricular ejection decline, to life-threatening events and lead to chemotherapy dose reduction and delay and, in some cases, for patients with severe side effects, discontinuation of treatment. Finally, they discussed on the identification of early markers of cardiac injury and on cardiac stem cell therapy as a promising approach to facilitate myocardial regeneration.
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