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[高分] 学位论文 Treatment with swimming and treadmill exercises reduced neuropathic pain on chronic constriction injury of sciatic nerve of rats
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作者：Li, Y., Li, Z., Hsueh, M., Hung, H., Ou, H. & Chen, Y. 网站： https://doi.org/10.1096/fasebj.24.1_supplement.618.15Digital Object Identifier (DOI) 发布期刊：The FASEB Journal 总体文章：Abstract BACKGROUND Treatment of neuropathic pain is still a challenge. Pharmacotherapies provide an effective efficacy for treatment of neuropathic pain, but drugs produce some side effects. Whether exercise training without drug treatment could provide beneficial effects on neuropathic pain. MATERIALS AND METHODS Chronic constriction injury (CCI) of the sciatic nerve in male SD rats produces behavioral hypersensitivity and is an accepted model of neuropathic pain. All rats were divided into 6 groups: sham, sham with swimming/treadmill exercise, CCI, CCI with swimming/treadmill exercise. We compared behavior responses and body weight in sham operated and CCI rats with or without exercise training. Thermal hyperalgesia and tactile allodynia was assessed by Plantar test and von Frey filament test. |
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