| 标题 |
 Mezigdomide-A Novel Cereblon E3 Ligase Modulator under Investigation in Relapsed/Refractory Multiple Myeloma 美齐度胺——一种在复发/难治性多发性骨髓瘤中研究的新型cereblon E3连接酶调节剂
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| 网址 | |
| DOI |
10.3390/cancers16061166
doi
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| 其它 | Mezigomide is an oral cereblon E3 ligase modulator (CELMoD) that is under clinical investigation in patients with relapsed/refractory (RR) multiple myeloma (MM). Like other CELMoD compounds, mezigdomide acts by altering the conformation of cereblon within the cullin 4A ring ligase-cereblon (CRL4CRBN) E3 ubiquitin ligase complex, thereby recruiting novel protein substrates for selective proteasomal degradation. |
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